Replaced factory Dunlap's at 51,000 miles with the LTX M-S2's. I now have 158,000 on my 2007 4Runner. I just had a state inspection on the vehicle, and they estimated I still have a good 20K left on them. Simply the best tire I have ever owned. I had LTX 2's on my 1999 4Runner and put over 80k on them and they still had plenty of tread when I sold it.
I don't think there is a better tire on the road today.
Definitely the best and quietest all weather tire I have owned. They are not a mud or snow tire, but an all season tire and they perform well as such. They are pricey, but you get what you pay for. Can't go wrong with Michelin!